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The role of trace elements in Alzheimer's disease
Sujeetha Purushothaman1, Aashika Ragavi2, Preethi Basavaraju3, Puthamohan Vinayaga Moorthi4, Arumugam Vijaya Anand5
1 Department of Human Genetics and Molecular Biology, Medical Genetics and Epigenetics Laboratory, Bharathiar University, Coimbatore, Tamil Nadu, India
2 Student, Medical Genetics and Epigenetics Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, Tamil Nadu, India
3 Research Scholar, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, Tamil Nadu, India
4 Assistant Professor, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, Tamil Nadu, India
5 Professor, Medical Genetics and Epigenetics Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, Tamil Nadu, India
Correspondence Address:
Mrs. Sujeetha Purushothaman
Department of Human Genetics and Molecular Biology, Medical Genetics and Epigenetics Laboratory, Bharathiar University, Coimbatore, Tamil Nadu
India
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/AMH.AMH_18_20
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Alzheimer's disease is a degenerative brain disease and the most common cause of dementia. The characteristic symptoms of dementia are difficulties with memory, language, problem solving, and other cognitive skills which affects a person's ability to perform everyday activities. Trace elements have found to play a major role in the Alzheimer's disease. Nowadays, the association of trace elements in the pathogenesis of Alzheimer's disease is more considered, and trace elements such as aluminum (Al), iron (Fe), copper (Cu), and zinc (Zn) imbalances in the amyloid beta peptides have been seen in the Alzheimer's disease This review focuses on the accumulation of trace elements aluminum (Al), copper (Cu), iron (Fe), and zinc (Zn) in the pathogenesis of Alzheimer's disease.
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